Hubert V. Forster, PhD
Professor
Locations
- Physiology
Contact Information
Education
MS, University of Wisconsin-Madison, 1965
BS, Social Sciences, Wisconsin State College, 1962
Research Interests
Genetics and Genomics | Neurophysiology | Respiratory Physiology
Research in my laboratory is primarily concerned with mechanisms regulating breathing. Our major studies involve implantation of microtubules into the medulla, pons or cerebellum of adult goats. Approximately three weeks later, when the goats have recovered from the surgery, we utilize the tubules to insert a dialysis probe to create a focal acidosis or focal hypoxia. Acid or PO 2 sensitive electrodes are also inserted to measure the changes in pH and PO 2 . In other studies, we inject agonist or antagonists of receptors or neurotoxins to create reversible or permanent neuronal dysfunction. Breathing, respiratory muscle activity, heart rate and arterial blood pressure are continuously measured in all studies, which are completed in awake or asleep states. These studies provide insights into sites in the brain, and mechanisms of respiratory rhythm and pattern generation and intracranial chemoreception during normal conditions and during exercise, or when O 2 and CO 2 levels change in the brain. We have completed other studies on piglets to gain insight into factors influencing the maturation of breathing. Finally, we have performed studies on rats that focus on elucidating genes that contribute to the control of breathing. All these studies relate primarily to disease conditions of central and obstructive sleep apnea, Sudden Infant Death syndrome, congenital central alveolar hypoventilation, and traumatic brainstem injury.
Publications
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(Puissant MM, Muere C, Levchenko V, Manis AD, Martino P, Forster HV, Palygin O, Staruschenko A, Hodges MR.) FASEB J. 2019 Apr;33(4):5067-5075 PMID: 30605394 PMCID: PMC6436665 SCOPUS ID: 2-s2.0-85064111657 01/04/2019
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(Forster HV.) J Appl Physiol (1985). 2018 Nov 01;125(5):1511-1525 PMID: 30138081 PMCID: PMC6295490 SCOPUS ID: 2-s2.0-85057407675 08/24/2018
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(Langer TM 3rd, Neumueller SE, Crumley E, Burgraff NJ, Talwar S, Hodges MR, Pan L, Forster HV.) Respir Physiol Neurobiol. 2017 May;239:10-25 PMID: 28137700 PMCID: PMC5996971 SCOPUS ID: 2-s2.0-85011649848 02/01/2017
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(Langer TM 3rd, Neumueller SE, Crumley E, Burgraff NJ, Talwar S, Hodges MR, Pan L, Forster HV.) J Appl Physiol (1985). 2017 Feb 01;122(2):327-338 PMID: 27687562 PMCID: PMC5504392 SCOPUS ID: 2-s2.0-85014833742 10/01/2016
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(Muere C, Neumueller S, Olesiak S, Miller J, Langer T, Hodges MR, Pan L, Forster HV.) J Appl Physiol (1985). 2015 Aug 01;119(3):308-20 PMID: 26023224 PMCID: PMC4526704 SCOPUS ID: 2-s2.0-84939865619 05/30/2015
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(Muere C, Neumueller S, Olesiak S, Miller J, Hodges MR, Pan L, Forster HV.) J Appl Physiol (1985). 2015 Mar 15;118(6):732-41 PMID: 25635003 PMCID: PMC4360020 SCOPUS ID: 2-s2.0-84925353298 01/31/2015
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(Martino PF, Olesiak S, Batuuka D, Riley D, Neumueller S, Forster HV, Hodges MR.) J Appl Physiol (1985). 2014 Oct 15;117(8):848-56 PMID: 25150225 PMCID: PMC4199991 SCOPUS ID: 2-s2.0-84908599397 08/26/2014
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(Miller JR, Neumueller S, Muere C, Olesiak S, Pan L, Bukowy JD, Daghistany AO, Hodges MR, Forster HV.) J Appl Physiol (1985). 2014 Jun 15;116(12):1531-42 PMID: 24790015 PMCID: PMC4064375 SCOPUS ID: 2-s2.0-84902472363 05/03/2014
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(Lalley PM, Pilowsky PM, Forster HV, Zuperku EJ.) J Physiol. 2014 Mar 15;592(6):1169 PMID: 24634014 PMCID: PMC3961074 SCOPUS ID: 2-s2.0-84896041719 03/19/2014
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(Lalley PM, Pilowsky PM, Forster HV, Zuperku EJ.) J Physiol. 2014 Mar 15;592(6):1163-6 PMID: 24634012 PMCID: PMC3961072 SCOPUS ID: 2-s2.0-84896040360 03/19/2014
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(Miller JR, Neumueller S, Muere C, Olesiak S, Pan L, Hodges MR, Forster HV.) J Appl Physiol (1985). 2013 Oct 01;115(7):1088-98 PMID: 23869058 PMCID: PMC3798825 SCOPUS ID: 2-s2.0-84885213330 07/23/2013
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(Bonis JM, Neumueller SE, Krause KL, Pan LG, Hodges MR, Forster HV.) Respir Physiol Neurobiol. 2013 Oct 01;189(1):10-21 PMID: 23774145 PMCID: PMC4338573 SCOPUS ID: 2-s2.0-84881235978 06/19/2013